I disagree with the point that says "don't ask too many questions". Don't ask questions that you can easily find the answer to yourself. Being self-taught is the ultimate show of initiative and I've never seen an environment where such effort went unnoticed. But only an idiot would stand by and wallow in ignorance simply for fear of irritating someone. The best bosses are also teachers because they know that, sooner or later, someone is going to have to replace them and it behooves everyone to have that person be competent. Not all people have the patience for that, though, and if that's the situation you're in, the key is to know when, where, and how to ask. And even if your boss isn't receptive, there is likely someone in the office who gets it and won't mind taking the time to help you understand. But keep asking questions. It's the only way to learn.